Benefits Of Slavery For The North - 904 Words

Benefits Of Slavery For The North Growing up just North of the Mason-Dixon line I learned a version of history that includes the Northern states standing on principle. The North stood on the righteous side of the line that said no longer would slavery be tolerated. On the other side of the line was the South that depended on slavery and would revolt sooner than change their ways. Later in life I moved South of the Mason-Dixon line to Richmond Virginia which was the one time capital of the Confederacy. Here I learned an alternate version of history, one of states’ rights against an oppressive government. What once I knew as the War on Slavery was here called the War Against Northern Aggression The truth of the matter may lies somewhere in between these two viewpoints but they both miss an important fact. Beyond the propaganda and catchy phrases is the simple fact that the Northern states had profited greatly from slaver. In some ways directly such as the trade itself and in others more indirect such as the boom of New England ship building. Direct Benefit of the Slave Trade The most direct benefit of slavery to the north was the trading of slaves in of itself. Slaves started arriving in New England in the first decade of the 1700s. By the middle of the century Rhode Island had become the main carrier of slaves and by the end of the American Revolution they controlled 60 – 90 percent of the slave trade (Harper). The DeWolfe family of Rhode Island was among someShow MoreRelatedBenefits Of Slavery For The North899 Words   |  4 PagesBenefits Of Slavery For The North Growing up north of the Mason-Dixon line, I learned a version of history in which the northern states were standing on principle. The North stood on the righteous side of the line that said no longer would slavery be tolerated. On the other side of the line was the South, who depended on slavery and would revolt sooner than change their ways. Later in life, I moved south of the Mason-Dixon line to Richmond, Virginia, which was at one time the capital of the ConfederacyRead MoreEssay about The American Civil War688 Words   |  3 PagesThe American Civil war was a series of transactions, or exchanges, between the North and the South. These transactions involved over 1 million Americans who put their lives at risk for the liberation of the country’s slaves. These transactions were influenced by three paramount concepts: perspectives, values, and relative evaluations of costs and benefits. In the midst of this tumultuous period of time in American history, these concepts shaped not just the people themselves but the social, politicalRead MoreThe Annexation Of Texas And The United States928 Words   |  4 Pagesshould be done with the new found territory. Whether it was people of the north looking to prevent another slave state from acquiring statehood, or slave owning people of the south trying to gain leverage in t he House of Representatives, people had differing opinions on the topic of Texas. The debate over Texas acquiring statehood was representative of the divide between North and South that led to Civil War in the U.S. In the North, many people didn’t want Texas to become a state, therefore were againstRead MoreThe South And North And South961 Words   |  4 Pages1800s, the South and the North were worlds apart from each other in various ways. The North and the South had altered economies, ideas, and attitudes toward slavery. The diverse economies in the North and South led to discrepancies among the regions about taxes on imported goods or tariffs. Furthermore the disagreements over slavery, tariffs, and other economic disputes amplified sectionalism, or the loyalty to one part of the country, in the North and the South. The North and South were ultimatelyRead MoreThe North Was Deeply Entrenched in Slavery Essay525 Words   |  3 PagesThe North and Slavery Slavery was deeply entrenched in the lives of Americans from both the north and the south. Plantation slavery and the Deep South is typically what comes to mind when the benefits of slavery are considered. However, northern states also benefited substantially from slavery even after it was outlawed in most northern states. Northern states specifically benefited from the shipping of slaves in northern ports, the financing of slaves and land for the south and the various supportRead MoreThe War Of The American Civil War991 Words   |  4 PagesAmericans and animosity that was built up over several years prior to it can be to blame. Most people think that slavery was the cause of this battle, and although slavery did play a part, it was not the main cause. The biggest roles played in the American Civil War were states’ rights, unfair bills, feelings of inferiority and threats to economy. The tension started during the time that the north attempted to pass a tariff that the south saw as an abomination. The Tariff of 1828 was passed, many SouthRead MoreThe Civil War Was Fought Over African American Freedom1331 Words   |  6 Pagesstraightforward answer, but many people still have different views and beliefs on what caused it. Many people believe that political issues or even taxation was the cause of the civil war. However, it was really over slavery. This essay will go over the civil war and explain why slavery caused the southerners and northerners to fight in the civil war. To what extent was the Civil War fought over African American freedom ? What were political issues that dominated U.S. politics in the 1850’s ? WhatRead MoreSlavery : The End Of The Civil War1543 Words   |  7 Pagesâ€Å"Slavery is founded in the selfishness of man s nature -- opposition to it is in his love of justice. These principles are an eternal antagonism; and when brought into collision so fiercely, as slavery extension brings them, shocks, and throes, and convulsions must ceaselessly follow. Repeal the Missouri Compromise -- repeal all compromises -- repeal the declaration of independence -- repeal all past history, you still can not repeal human nature. It still will be the abundance of man s heart,Read MoreNorth and South on Slavery1040 Words   |  4 PagesThe North and South have very different views on slavery. This has lead to lots of tension and fighting. When people were first settling here they had slaves. It has been going on for almost 100 years. Start ing around the Revolutionary war the North became opposed to slavery. They had less use for them as time went on. The South, on the other hand, felt they needed slavery. They had to harvest tobacco and cotton as fast as possible. They knew they couldn’t do it themselves so they bought lots ofRead MoreThe Economic Impact On The Economy Of The United States1246 Words   |  5 PagesDuring the days of 1820 to 1860 in the United States, the living style of Americans became more different from north to south. We can observe on the economic perspective. First, the difference of the industrial sectors led to the different extent of the need of slavery. The manufacturing sector, thanks for the advent of industrialization, did not require as many slaves as the agricultural sector did in the south which was largely supported by a massive number of slaves. Secondly, due to the difference

Wild Oats Case Study - 1212 Words

INTRODUCTION: Founded in 1987, Wild Oats Markets, Inc. is a leading natural and organic foods retailer in the United States. Headquartered in Boulder, Colorado, the company operates over 100 natural food stores in 25 states and Canada under several names, including Wild Oats Natural Marketplace, Henry’s Farmer’s Market, Sun Harvest Farms, and Capers Community Market. The owners, Michael Gilliand and Libby Cook, lacked experience in the natural/whole foods market and the first store got off to a slow start. However, with consumer’s peaking interest in wholesome foods produced in an earth-friendly, responsible manner, sales soon increased and the company experienced rapid growth from 1991 through 1999. Even though they have remained†¦show more content†¦By 2006, the company was in over its head and could not compete effectively with Whole Foods. Insufficient IT – Even though the company has commenced IT programs for EDI, they still have a weak I T infrastructure with a proliferation of systems. OPPORTUNITIES: High Growth Market – the holistic health area is growing quickly and Wild Oats has already begun tapping that market. The popularity of organic market cafes is increasing and Wild Oats already has these cafes in many of its stores. Vertical Backward Integration – Whole Foods has the opportunity to expand its distribution center in Denver, and enlarge the commissary kitchens to produce even more of the deli food, baked goods, and take-out food for delivery to their stores, thereby replacing some suppliers and assuring their quality standards are met. E-Commerce – Wild Oats currently offers their private label brands through Peapod.com and Amazon.com. The opportunities on-line are endless as long as the commissary kitchens and distribution centers can keep up with the demand. THREATS: Competition from conventional grocers and mass retailers – as they add organics to their product offerings, the resulting competition could drive prices down and create gross margin erosion. Competition from Whole Foods – Whole Foods competitive store openings have the capacity to negatively impact Wild Oats sales, and as has been demonstrated, have been a source of pressure.Show MoreRelatedCase Study(Whole Foods)1481 Words   |  6 Pageswhich is not alarming but the management should look into the reasons behind the decline. The debt-to-equity ratio is used to evaluate borrowing capability and the amount of debt in the company. Usually ratios above 1.0 indicate excessive debt, in the case of Whole Foods Market the ratio has gone up from 2006-2007 (.004-.023), which indicated an increase in the amount of borrowings. The ratio is nowhere close to one, which indicates credit worthiness of Whole Foods Market and their ability to pay backRead MoreCase Study Whole Foods11 55 Words   |  5 PagesCase Study assignment 1. What are the chief elements of the strategy that Whole Foods Market is pursuing? Fresh natural and organic foods and products with no preservatives or artificial ingredients. Promote healthier eating/lifestyle and increasing consumer knowledge/education of food safety, environment and how pesticides affect the land as well as the human body. 2. Is the strategy well matched to recent developments and conditions in the natural and organic foods segment of the food retailingRead MoreWhole Foods Market in 2008: Vision, Core Values, and Strategy2599 Words   |  11 PagesRunning head: CASE STUDY ANALYSIS FOR WHOLE FOODS MARKET Case Study Analysis for Whole Foods Market Abstract This paper is an analysis of Whole Foods Market’s vision, core values, and business strategy. It lays out the type of strategy that Whole Foods Market utilizes, what parts of this strategy work and what parts could use improvement. This case study analysis concludes that Whole Foods Market has a very good business strategy, has a strong, clear vision, and lives by its core valuesRead MoreWhole Foods Market : Vision, Core Values, And Strategy Essay1483 Words   |  6 PagesStefan Sjekloca 09/17/2016 Case Study Whole Foods Market in 2014: Vision, Core Values, and Strategy 1) Merchandise strategy, Whole Foods Market concentrates in having an interactive atmosphere in their stores. The way the setup their products makes people want to keep buying, they make it an inviting atmosphere with a lot of colorful dà ©cor, they try to make it a community as itself. In the stores they have a lot of sitting areas like bakeries, coffee shops, open kitchens, and etc. Their main focusRead MoreEssay on Penicillin Resistance2265 Words   |  10 PagesChemicals and Materials # p- aminohippurate, estrone-3- substrate, insulin, penicillin G, and HPLC (see discussion for more details) Animals # Male and female oat3, and wild type age matched mice- 12-16 weeks old for pharmacokinetic (fate of drug internally in body, essentially absorption and distribution in this case) experiments and 6 months old for organ function markers # Knockout mice genetically altered the oat3 transfer protein, so nonfunctional Data Many of the data collectedRead MoreWhole Foods Market Case Essay1917 Words   |  8 PagesCase Study: Whole Foods Market 2006: Mission, Core Values and Strategy 1. What are the chief elements of the strategy that Whole Foods Market is pursuing? Founder John Mackey strongly believed in Whole Foods’ mission to be very selective about store inventory, sticking to the company’s core values and ensuring that customers had an enjoyable and interactive shopping experience, while keeping with planned strategies that have set them apart from their competitors. Store Development andRead MoreWhole Foods Market2057 Words   |  9 PagesCase Study: Whole Foods Market 2006: Mission, Core Values and Strategy 1. What are the chief elements of the strategy that Whole Foods Market is pursuing? Founder John Mackey strongly believed in Whole Foods’ mission to be very selective about store inventory, sticking to the company’s core values and ensuring that customers had an enjoyable and interactive shopping experience, while keeping with planned strategies that have set them apart from their competitors. Store Development andRead MoreWhole Foods Markets1582 Words   |  7 PagesAbstract This paper examines the published case study Whole Foods Markets, 2005: Will There Be Enough Organic Food to Satisfy the Growing Demand? (Hitt, Ireland and Hoskisson, 2007, p. C534). Although the published study addresses numerous aspects of Whole Foods Market’s business as a leading international retailer of â€Å"natural† organic foods, the analysis provided herein is focused on Whole Foods Market’s ability to meet future growth demands. This paper explores Whole Foods Market’s basic internalRead MoreMarketing Plan For Whole Foods1390 Words   |  6 Pagesgrown domestically. In 2007 Whole Foods began opening stores in the United Kingdom. While continually opening new stores, the company fueled its expansion by acquiring other food chains. For instance, it acquired one of its largest competitors, Wild Oats, in 2007. Whole Foods has consistently ranked as one of the World’s Most Ethical companies for its emphasis on organic food, healthy living, customer satisfaction, quality, and sustainability. The firm has also been elected as one of the top companiesRead MoreWhole Foods Market Case Analysis1768 Words   |  8 Pagesof the organic food brand. Threat of new entrant There are a few new entrants, which are Trader Joe’s company and Wild Oats Market. This two are the new entrant in this industry however this represents a moderate threat as for the Trader Joe’s company, it has no service department and it has limited space of store, as compared to Whole Foods Market. Secondly, as for Wild Oats Market, the founder was lack of experience in this industry and they was emphasizing on the learning of the employees

Financial Case Analysis of Dick Smith for Kogan- myassignmenthelp

Question: Discuss about theFinancial Case Analysis of Dick Smith Holdings for Kogan. Answer: Introduction This report aims to provide a broad view on the case study of Dick Smith brand which was liquidised on 25th July 2016 with a massive loss to the investors of the company (Chung, 2016). Though, the company was again purchased by Kogan.com at the same time with an undisclosed amount, it was speculated that the amount of the company in Australian security Exchange (ASX) listing was false and hyped. In this context, the study describes a brief history of ownership of the company Dick Smith brand. Furthermore, this research is focused on the evaluation of two different situations of the DSHs valuation related to when it was offered to the public in the beginning and when the company was acquired by Anchorage Capital Partners from Woolworths in 2012 (Chung, 2016). In addition to this, the study also elaborates ethical issue faced by the top level management of the company when the company was listed in ASX in 2012 and by Anchorage Capital Partners pertaining to floating business. A Brief summary of the Dick Smith brand Dick Smith Company was commenced by Dick Smith in Atarmon, Sydney in 1968 under a rented car park space (Ryan, 2015). The company mainly focused to install car radios as a small business with just $610 as an initial capital. During 1970 to 80s company was expanded by various product lines and ranges with around 20 stores in Australia. In 1980, 60% of the companys shares holding by Dick Smiths wife were sold to Woolworths. Moreover, remaining 40% of Dick Smith Companys shares were fully owned by Woolworths in 1982 with a total worth of $25 million Woolworths purchased the Dick Smith brands whole company (Dick Smith- Annual Report, 2014). After that, Woolworths Company restructured Dick smith brand but then, closed up to 100 stores of the company and later on sold the company to Anchorage Capital Partners for $115 million. $20 millions were paid upfront by the company to purchase it from Woolworths (Dick Smith- Annual Report, 2014). The company appointed Nick Abboud as its chief execut ive in November, 2012. Besides that, it has been reported that just after a year, Dick Smith listed its shares on ASX with a capital floating of $520 million in December, 2013. In January 2016, company collapsed into voluntary administration in which McGrathNicol was appointed by companys board, whereas investors appoint Ferrier Hodgson as a receiver (West, 2016). In present Scenario, Dick Smith brand is being owned by Kagon.Com from May 2016 that sold its product online only. Assessment of the valuation of Dick Smith brand at the time of Initial Public Offering and when acquired by Anchorage capital partners At the time of acquisition from Woolworths in November 2016, Anchorage capital partners purchased it by offering initial capital of $20 million and total amount of $115 million (Ong and Janda, 2016). However, it has been analysed that cash of Anchorages was only $20 million with no credits or loans from the market. In December 2013, the company floated Dick Smith Holdings shares in Australian security exchange with market capitalisation of $520.3. From the Annual reports, it has also been realised that during this one year Dick Smith holdings EBITDA was increased from $23million to $74.4 million (Dick Smith- Annual Report, 2014). On the contrary, it has also been examined that EBITDA growth was found on irregularities in inventory management. The written of values from assets was not explained properly such as in November 2012, written off value of plant and equipment was $54 million, whereas inventory which was booked as $312 million from $371 million having depreciation of $58 mill ion (Anchorage Capital Partner, 2016). On the other hand, non-current provisions were written down by $8 million and all these adjustments were stated as fair value. Within 7 months, the inventory was declined by $171 million in 30th June, 2013. Due to plant and equipments written down in 2013, depreciation in 2014 was only of $10 million. These adjustments and representation could be the reason of growth in EBITDA in 2014 to $74.4 million swiftly (Dick Smith- Annual Report, 2014). It has also been noticed that loans and borrowings of Dick Smith Holding in 2015 was increases with $70.5 million which was not presented in 2014 accounting books. Apart from this representation which was related to scrutiny and high level of debt, all the representation in the books of 2015 was normal and convincing (Ong and Janda, 2016). At the same time, when the case was examined closely, company did not indicate a sound business practice as debt ratio was recorded as 67% in year end of 2015 which is very risky and elevated. In 2015 ending, Dick Smith Holdings was not able to arrange its short-term debts due to dearth of working capital which was 1.23:1 (Dick Smith- Annual Report, 2014). In addition to this, inventory turnover ratio was examined as 2.9:10 which was not increased with a significant rate from 2014. The company was dysfunction due to no long service leave was granted in the year ending 2015. Meanwhile, announcement of failure in the operation and continuous breakdow n of prices on November 2015 was made by top level management of the company, which added rapid decline in the prices of share in ASX due to Non-cash impairment in the inventory (Dick Smith- Annual Report, 2014). This whole incident above, further affected the share prices and performance of the company in the market at the end of the financial year 2015. In the context of initial public offering, companys profit and loss accounts were not audited and DSE source has also been added in the books to manipulate some of the values in the books. The companys financial accounting recordings were not been audited from 2010-14 that created suspicion in the authorised and validity of the accounts (Chung, 2016). Therefore, it can be inferred that the dick smith company was not being operated with proper accounting standards and valid evidences to prove the true and fair view of the accounts recording in the last years of financial company 2015. Ethical dilemmas of Anchorage Capital Partners and top level management of the company Anchorage Capital Partner is a private equity firm situated in Australia which focuses on turnovers. The company took over Dick Smith brand from Woolworths in 2012 for $115 million as a total payment (The conversation, 2016). Dick smith holdings shares were floated in Australian security exchange worth $520 million. It has been analysed that the company had presented various illogical book recordings that created suspicion among stakeholders and investors. Some of the transactions such as writing off of $58 million from inventory as a fair value adjustment and over increase in EBITDA from $23.4 million to $74.4 million in the end of the financial year created some serious doubt on the fair and true view of the financial accounting in books of Dick Smith Holding (Anchorage Capital Partner, 2016). Amidst of all, anchorage capital partner is a profit earning company that is aimed to increase shareholders profit in any investment. Not only has the company its own shareholders but also in order to float a medium or small sized businesses, it is allowed to buy-ins and buyout that equity shares as a way of operation (The conversation, 2016). Furthermore, it has been seen that these private owned company deducts its asset strictly to increase the profit of the company. Moreover, in case of directors and senior executives of Dick Smith holdings in which statement was made in the 2014- 2015 report and accounts that they are highly satisfied with the operational performance of the company and hope for the new investments which can enhance the future aspects of the company (Underhill, 2016). It can be analysed that directors, senior executives and other top management of the company were agreed to the financial record of the company as well as that explained it satisfied with the near future growth expectations. Likewise, it was stated in the Initial Public Offerings prospectus that in order to achieve a declination in the inventory, a sum of $2.5 million was spent by the company, which is not customary. It has also determined from the books of past financial information that financial recording of the company was also not authenticated as various figures was not clear and does not have any apt source. An unaudited PL statement from 2010 to 2014 was al so derived from unaudited accounts of DSE (Anchorage Capital Partner, 2016). Some of the major setbacks were writing off plant and equipments and exclusion of inventory impairment (Underhill, 2016). All of the above recordings were found in restructuring provisions, impairment losses and under acquisition balance sheet (Boyd, 2016). The information given in the annual reports were intended to influence the view of investor by presenting affirmative impression of the company. In this process of liquidation of Dick Smith brand, Deloitte has played an imperative role as an accounts auditor. The company claims that its annual reports of 2015 were based on true and fair view statement which was compiled by the accounting standards. On the other hand, there was no information provided related to the future events and upcoming planning of the company. Substantially, after three days of all the statement shown in the annual reports subsidiaries holdings and perpetual limited were being ceased (Boyd, 2016). Not only this, National Australian Bank and HSBC Bank of Australia with major shareholders AMP were being ceased from shareholders in Dick Smith Holdings. Thus, suspicion over the auditors and top level management was considered strong and opportune. The company that claimed to be clean and with a true and fair view of books had recorded $338,000, for the audit service of $103,927. Conclusion From the above discussion, it can be inferred that Dick Smith Holding case has many folds that provides a clear view on the poor inventory management and some misrepresentation of financial accounting values that led the companys dissolution in 2015. The company has a doubtful case even after, liquidation with the present owner of the company that is Kagon.com which has an online retailing in technology. It has been absorbed that company suddenly hyped its share prices within a year to $520 million from $115 million only in ASX. Poor inventory management and creating loans and borrowing as well as writing of assets with huge amount, unhinged the position of the company. In addition to this, it has also been concluded that as a profit earning organisation Anchorage capital partner cut off the assets to show profit to its shareholders. Top level management and auditors of the company were also involved in the misrepresentation of the figures as per their statement in the annual reports . Therefore, it can be said that Dick smith case was focused on the poor inventory management and misrepresentation of facts that led to the liquidation of the company. References Anchorage Capital Partner. 2016. Senate economics references committee inquiry in relation to the causes and consequences of the collapse of listed retailers in Australia [Online] Available at: https://www.google.de/url?sa=trct=jq=esrc=ssource=webcd=5cad=rjauact=8ved=0ahUKEwjP6NLAuPrVAhVNL1AKHeOlC1oQFghCMAQurl=http%3A%2F%2Fwww.aph.gov.au%2FDocumentStore.ashx%3Fid%3Dfd49fc87-6bc3-460c-81fc-293c5a92edc5%26subId%3D410892usg=AFQjCNFNELD2mWphtkCrcXWvqTsSSTUMgg [Accessed on: 28 August 2017]. Anchorage Capital Partners. 2017. [Online] Available at: https://www.anchoragecapital.com.au/news/ [Accessed on: 28 August 2017]. Boyd, T. 2016. Dick Smith collapses a case study in electronics retailing. [Online] Available at: https://www.afr.com/brand/chanticleer/dick-smith-collapse-a-case-study-in-electronics-retailing-20160713-gq54s0# [Accessed on: 28 August 2017]. Chung, J. 2016. Dick Smith blasts private equity firm behind retailers stock market float. [Online] Available at: https://www.news.com.au/finance/business/retail/dick-smith-blasts-private-equity-firm-behind-retailers-stock-market-float/news-story/41a067495cc4bef5c8109bce7a97ae50 [Accessed on: 28 August 2017]. Dick Smith- Annual Report. 2014. [Online] Available at: https://corpdocs.msci.com/Annual/ar_2014_317027.pdf [Accessed on: 28 August 2017]. Ong, T and Janda, M. 2016. Dick Smith enters receivership due to bad sales, banking woes. [Online] Available at: https://www.abc.net.au/news/2016-01-05/dick-smith-enters-voluntary-administration/7067798 [Accessed on: 28 August 2017]. Ryan, M. 2015. Dick Smith is the Greatest Private Equity Heist of All Time. [Online] Available at: https://foragerfunds.com/bristlemouth/dick-smith-is-the-greatest-private-equity-heist-of-all-time/ [Accessed on: 28 August 2017]. The conversation. 2016. How private equity won while other Dick Smith investors got burnt [Online] Available at: https://theconversation.com/how-private-equity-won-while-other-dick-smith-investors-got-burnt-52805 [Accessed on: 28 August 2017]. Underhill, J. 2016. Anchorage hyped Dick Smith IPO with 'gold talk'. [Online] Available at: https://www.nbr.co.nz/article/anchorage-capital-hyped-dick-smith-ipo-gold-talk-b-183462 [Accessed on: 28 August 2017]. West, M. 2016. Dick Smith float looks like window dressing. [Online] Available at: https://www.smh.com.au/business/retail/dick-smith-float-looks-like-window-dressing-20160205-gmmg88.html [Accessed on: 28 August 2017].

Leading Change by John P. Kotter free essay sample

Leading Change by John P. Kotter Book review by Pat Naughtin Harvard-Professor John P. Kotter has been observing the process of change for 30 years. He believes that there are critical differences between change efforts that have been successful, and change efforts that have failed. What interests him is why some people are able to get their organizations to change dramatically — while most do not. John P. Kotter writes: Over the past decade, I have watched more than a hundred companies try to remake themselves into significantly better competitors. They have included large organizations (Ford) and small ones (Landmark Communications), companies based in United States (General Motors) and elsewhere (British Airways), corporations that were on their knees (Eastern Airlines), and companies that were earning good money (Bristol-Myers Squibb). Their efforts have gone under many banners: total quality management, reengineering, right-sizing, restructuring, cultural change, and turnaround. But in almost every case the basic goal has been the same: to make fundamental changes in how business is conducted in order to help cope with a new, more challenging market environment. We will write a custom essay sample on Leading Change by John P. Kotter or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page A few of these corporate change efforts have been very successful. A few have been utter failures. Most fall somewhere in between, with a distinct tilt toward the lower end of the scale. The lessons that can be drawn are interesting and will probably be relevant to even more organizations in the increasingly competitive business environment of the coming decade. Kotter developed a list of factors that he believes lead to successful changes, and those that lead to failure. Yet for historical reasons, many organizations today dont have much leadership. Finally, John P. Kotter writes: There are still more mistakes that people make, but these eight are the big ones. In reality, even successful change efforts are messy and full of surprises. But just as a relatively simple vision is needed to guide people through a major change, so a vision of the change process can reduce the error rate. And fewer errors can spell the difference between success and failure. I have observed many attempts at metrication in many organisations over many years and I believe that John P. Kotters Leading Change provides a useful reference for metrication leaders to consider as they plan any metrication upgrade. If you would like to purchase Kotters book there is a link to Amazon at the bottom of my web page at: http://www. metricationmatters. com Metric system consultant, writer, and speaker, Pat Naughtin, has helped thousands of people and hundreds of companies upgrade to the modern metric system smoothly, quickly, and so economically that they now save thousands each year when buying, processing, or selling for their businesses. Pat provides services and resources for many different trades, crafts, and professions for commercial, industrial and government metrication leaders in Asia, Europe, and in the USA. Pats clients include the Australian Government, Google, NASA, NIST, and the metric associations of Canada, the UK, and the USA. See http://www. metricationmatters. com/ for more metrication information, contact Pat at pat. [emailprotected] com or to get the free Metrication matters newsletter go to: http://www. metricationmatters. com/newsletter/ to subscribe. http://www. metricationmatters. com

The Effects Of HIV Mutations On The Immune System Essay Example For Students

The Effects Of HIV Mutations On The Immune System Essay INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. We will write a custom essay on The Effects Of HIV Mutations On The Immune System specifically for you for only $16.38 $13.9/page Order now BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the hosts chromosomes; they are thereby distributed to all daughter cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to read that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIVs Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. .u38db47f5f00574bc9f1453c4c2eec17c , .u38db47f5f00574bc9f1453c4c2eec17c .postImageUrl , .u38db47f5f00574bc9f1453c4c2eec17c .centered-text-area { min-height: 80px; position: relative; } .u38db47f5f00574bc9f1453c4c2eec17c , .u38db47f5f00574bc9f1453c4c2eec17c:hover , .u38db47f5f00574bc9f1453c4c2eec17c:visited , .u38db47f5f00574bc9f1453c4c2eec17c:active { border:0!important; } .u38db47f5f00574bc9f1453c4c2eec17c .clearfix:after { content: ""; display: table; clear: both; } .u38db47f5f00574bc9f1453c4c2eec17c { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u38db47f5f00574bc9f1453c4c2eec17c:active , .u38db47f5f00574bc9f1453c4c2eec17c:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u38db47f5f00574bc9f1453c4c2eec17c .centered-text-area { width: 100%; position: relative ; } .u38db47f5f00574bc9f1453c4c2eec17c .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u38db47f5f00574bc9f1453c4c2eec17c .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u38db47f5f00574bc9f1453c4c2eec17c .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u38db47f5f00574bc9f1453c4c2eec17c:hover .ctaButton { background-color: #34495E!important; } .u38db47f5f00574bc9f1453c4c2eec17c .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u38db47f5f00574bc9f1453c4c2eec17c .u38db47f5f00574bc9f1453c4c2eec17c-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u38db47f5f00574bc9f1453c4c2eec17c:after { content: ""; display: block; clear: both; } READ: Ethical Hackers Essay As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from the cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to almost normal concentrations. It is at this time the virus enters its second stage. Throughout this second phase the immune system functions well, and the net concentration of measurable virus remains relatively low. But after a period of time, the viral level rises gradually, in parallel with a decline in the helper population. These helper T and B . The Effects Of HIV Mutations On The Immune System Essay Example For Students The Effects Of HIV Mutations On The Immune System Essay INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. We will write a custom essay on The Effects Of HIV Mutations On The Immune System specifically for you for only $16.38 $13.9/page Order now BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the hosts chromosomes; they are thereby distributed to all daughter cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to read that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIVs Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. .u1784bd8f62e36d002e3ece86cd1528f9 , .u1784bd8f62e36d002e3ece86cd1528f9 .postImageUrl , .u1784bd8f62e36d002e3ece86cd1528f9 .centered-text-area { min-height: 80px; position: relative; } .u1784bd8f62e36d002e3ece86cd1528f9 , .u1784bd8f62e36d002e3ece86cd1528f9:hover , .u1784bd8f62e36d002e3ece86cd1528f9:visited , .u1784bd8f62e36d002e3ece86cd1528f9:active { border:0!important; } .u1784bd8f62e36d002e3ece86cd1528f9 .clearfix:after { content: ""; display: table; clear: both; } .u1784bd8f62e36d002e3ece86cd1528f9 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u1784bd8f62e36d002e3ece86cd1528f9:active , .u1784bd8f62e36d002e3ece86cd1528f9:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u1784bd8f62e36d002e3ece86cd1528f9 .centered-text-area { width: 100%; position: relative ; } .u1784bd8f62e36d002e3ece86cd1528f9 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u1784bd8f62e36d002e3ece86cd1528f9 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u1784bd8f62e36d002e3ece86cd1528f9 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u1784bd8f62e36d002e3ece86cd1528f9:hover .ctaButton { background-color: #34495E!important; } .u1784bd8f62e36d002e3ece86cd1528f9 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u1784bd8f62e36d002e3ece86cd1528f9 .u1784bd8f62e36d002e3ece86cd1528f9-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u1784bd8f62e36d002e3ece86cd1528f9:after { content: ""; display: block; clear: both; } READ: Civil Rights Movement Essay As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from the cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to almost normal concentrations. It is at this time the virus enters its second stage. Throughout this second phase the immune system functions well, and the net concentration of measurable virus remains relatively low. But after a period of time, the viral level rises gradually, in parallel with a decline in the helper population. These helper T and B . The Effects Of HIV Mutations On The Immune System Essay Example For Students The Effects Of HIV Mutations On The Immune System Essay INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. We will write a custom essay on The Effects Of HIV Mutations On The Immune System specifically for you for only $16.38 $13.9/page Order now BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the hosts chromosomes; they are thereby distributed to all daughter cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to read that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIVs Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. .udacaaddb74868d06d5f759168fd8bd29 , .udacaaddb74868d06d5f759168fd8bd29 .postImageUrl , .udacaaddb74868d06d5f759168fd8bd29 .centered-text-area { min-height: 80px; position: relative; } .udacaaddb74868d06d5f759168fd8bd29 , .udacaaddb74868d06d5f759168fd8bd29:hover , .udacaaddb74868d06d5f759168fd8bd29:visited , .udacaaddb74868d06d5f759168fd8bd29:active { border:0!important; } .udacaaddb74868d06d5f759168fd8bd29 .clearfix:after { content: ""; display: table; clear: both; } .udacaaddb74868d06d5f759168fd8bd29 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .udacaaddb74868d06d5f759168fd8bd29:active , .udacaaddb74868d06d5f759168fd8bd29:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .udacaaddb74868d06d5f759168fd8bd29 .centered-text-area { width: 100%; position: relative ; } .udacaaddb74868d06d5f759168fd8bd29 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .udacaaddb74868d06d5f759168fd8bd29 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .udacaaddb74868d06d5f759168fd8bd29 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .udacaaddb74868d06d5f759168fd8bd29:hover .ctaButton { background-color: #34495E!important; } .udacaaddb74868d06d5f759168fd8bd29 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .udacaaddb74868d06d5f759168fd8bd29 .udacaaddb74868d06d5f759168fd8bd29-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .udacaaddb74868d06d5f759168fd8bd29:after { content: ""; display: block; clear: both; } READ: Trials And Tribulations Of Charles Dickens ( His L Essay As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from the cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to almost normal concentrations. It . The Effects of HIV Mutations on the Immune System Essay Example For Students The Effects of HIV Mutations on the Immune System Essay Science C.J. Stimson INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. We will write a custom essay on The Effects of HIV Mutations on the Immune System specifically for you for only $16.38 $13.9/page Order now For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the hosts chromosomes; they are thereby distributed to all daughter cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to read that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIVs Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from the cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to . The Effects Of HIV Mutations On The Immune System Essay Example For Students The Effects Of HIV Mutations On The Immune System Essay INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. We will write a custom essay on The Effects Of HIV Mutations On The Immune System specifically for you for only $16.38 $13.9/page Order now BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the hosts chromosomes; they are thereby distributed to all daughter cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to read that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIVs Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. .u3d0cca5b57aba049692fb4850ab2a85b , .u3d0cca5b57aba049692fb4850ab2a85b .postImageUrl , .u3d0cca5b57aba049692fb4850ab2a85b .centered-text-area { min-height: 80px; position: relative; } .u3d0cca5b57aba049692fb4850ab2a85b , .u3d0cca5b57aba049692fb4850ab2a85b:hover , .u3d0cca5b57aba049692fb4850ab2a85b:visited , .u3d0cca5b57aba049692fb4850ab2a85b:active { border:0!important; } .u3d0cca5b57aba049692fb4850ab2a85b .clearfix:after { content: ""; display: table; clear: both; } .u3d0cca5b57aba049692fb4850ab2a85b { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u3d0cca5b57aba049692fb4850ab2a85b:active , .u3d0cca5b57aba049692fb4850ab2a85b:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u3d0cca5b57aba049692fb4850ab2a85b .centered-text-area { width: 100%; position: relative ; } .u3d0cca5b57aba049692fb4850ab2a85b .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u3d0cca5b57aba049692fb4850ab2a85b .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u3d0cca5b57aba049692fb4850ab2a85b .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u3d0cca5b57aba049692fb4850ab2a85b:hover .ctaButton { background-color: #34495E!important; } .u3d0cca5b57aba049692fb4850ab2a85b .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u3d0cca5b57aba049692fb4850ab2a85b .u3d0cca5b57aba049692fb4850ab2a85b-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u3d0cca5b57aba049692fb4850ab2a85b:after { content: ""; display: block; clear: both; } READ: Analysis Of The Movie ' The Pursuit Of Happiness ' Essay As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from the cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to almost normal concentrations. It is at this time the virus enters its second stage. Throughout this second phase the immune system functions well, and the net concentration of measurable virus remains relatively low. But after a period of time, the viral level rises gradually, in parallel with a decline in the helper population. These helper T and B lymphocytes are not lost because the bodys ability to produce new helper . The Effects Of HIV Mutations On The Immune System Essay Example For Students The Effects Of HIV Mutations On The Immune System Essay INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. We will write a custom essay on The Effects Of HIV Mutations On The Immune System specifically for you for only $16.38 $13.9/page Order now BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the hosts chromosomes; they are thereby distributed to all daughter cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to ;read; that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIVs Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. .ue25a387c383de9caaf6794d5d146da41 , .ue25a387c383de9caaf6794d5d146da41 .postImageUrl , .ue25a387c383de9caaf6794d5d146da41 .centered-text-area { min-height: 80px; position: relative; } .ue25a387c383de9caaf6794d5d146da41 , .ue25a387c383de9caaf6794d5d146da41:hover , .ue25a387c383de9caaf6794d5d146da41:visited , .ue25a387c383de9caaf6794d5d146da41:active { border:0!important; } .ue25a387c383de9caaf6794d5d146da41 .clearfix:after { content: ""; display: table; clear: both; } .ue25a387c383de9caaf6794d5d146da41 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .ue25a387c383de9caaf6794d5d146da41:active , .ue25a387c383de9caaf6794d5d146da41:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .ue25a387c383de9caaf6794d5d146da41 .centered-text-area { width: 100%; position: relative ; } .ue25a387c383de9caaf6794d5d146da41 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .ue25a387c383de9caaf6794d5d146da41 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .ue25a387c383de9caaf6794d5d146da41 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .ue25a387c383de9caaf6794d5d146da41:hover .ctaButton { background-color: #34495E!important; } .ue25a387c383de9caaf6794d5d146da41 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .ue25a387c383de9caaf6794d5d146da41 .ue25a387c383de9caaf6794d5d146da41-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .ue25a387c383de9caaf6794d5d146da41:after { content: ""; display: block; clear: both; } READ: Cigarette Ad Essay As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from the cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to almost normal concentrations. It .

Snowy Owl Facts

Snowy Owl Facts Snowy owls (Bubo scandiacus) are the heaviest owls in the United States. They are notable for their striking white plumage and their extreme northerly range which includes tundra habitat throughout Alaska, Canada, and Eurasia. While they are relatively rare, they are often spotted in winter when they hunt in windswept fields or dunes. Fast Facts: Snowy Owl Scientific Name: Bubo scandiacusCommon Names: Arctic owls, great white owls, white owls, Harfangs, American snowy owls, snowy owls, ghost owls, tundra ghosts, ookpiks, ermine owls, Scandinavian nightbirds, and highland tundra owlsBasic Animal Group:  BirdSize: Body: 20 to 28 inches; wingspan: 4.2 to 4.8 feetWeight: 3.5–6.5 poundsLifespan: 10 yearsDiet:  CarnivoreHabitat:  Northern United States, parts of Canada; migration takes them to parts of Europe and AsiaPopulation:  200,000Conservation  Status:  Vulnerable   Description The plumage of an adult male snowy owl is mostly white with few dark markings. Females and young owls have a sprinkling of darker feathers that form spots or bars over their wings, breast, upper parts and the back of their head. This speckling offers superb camouflage and enables juveniles and females to blend well with the summertime colors and textures of the tundras vegetation. During the nesting season, females are often are heavily soiled on their underside from sitting on the nest. Snowy owls have bright yellow eyes and a black bill. Vicki Jauron, Babylon and Beyond Photography / Getty Images Habitat and Distribution Snowy owls range from the western Aleutians in Alaska to northeastern Manitoba, northern Quebec, Labrador, and the northern United States. They are primarily tundra birds although they sometimes also inhabit grasslands. They venture into forests only on very rare occasions, if ever. During the winter, snowy owls often move southward. During their migration, they are sometimes seen along coastlines and lake shores. They sometimes stop at airports, possibly because they offer them the wide-open habitat they prefer. During the breeding season, which snowy owls spend in the Arctic, they nest on small rises in the tundra where the female carves out a scrape or shallow depression in the ground in which to lay her eggs. Snowy owls rely on prey populations that fluctuate significantly over time. As a result, snowy owls are nomadic birds and go wherever there are ample food resources at any particular time. During normal years, snowy owls remain in the northernmost parts of Alaska, Canada, and Eurasia. But in seasons when prey is not abundant in the northern stretches of their range, snowy owls move further southward. Occasionally, snowy owls move to regions that are farther south than their normal range. For example, during the years of 1945 through 1946, snow owls made a widespread, coast-to-coast incursion into the southern stretches of Canada and the northern parts of the United States. Then in 1966 and 1967, snowy owls moved deeply into the Pacific Northwest region. These incursions have coincided with cyclic declines in the lemming population. Diet During the breeding season, snowy owls survive on a diet that consists of lemmings and voles. In parts of their range where lemmings and voles are absent, such as the Shetland Islands, snowy owls feed on rabbits or chicks of wading birds. Behavior Unlike most owls, snowy owls are primarily diurnal birds, usually active during the day, from dawn to dusk. Sometimes snowy owls do hunt at night. It is important to remember that within their Arctic range, snowy owls experience long summer days and hunting at night simply isnt an option as there are few or no hours of darkness. The opposite is true in winter when day length shortens and hunting during daylight hours is reduced or eliminated as the sun remains below the horizon for long stretches of time. Outside the breeding season, snowy owls make very few vocalizations. During the breeding season, snowy owls are a bit more vocal. Males make a barking kre or krek-krek call. Females produce a loud whistling or mewling pyee-pyee or prek-prek sound. Snowy owls also produce a low-pitched hoot that carries through the air for long distances and can be heard as much as 10 kilometers away. Other sounds snowy owls make include hissing, bill snapping and a clapping sound believed to be created by clicking the tongue. Reproduction and Offspring Normally, snowy owls lay between five and eight eggs per clutch. But in good years when prey such as lemmings is abundant, they lay as many as 14 eggs per clutch. Female snowy owls lay their 2.2 inch long eggs at two-day intervals so that the young emerge from the egg at different times. Mud-brown hatchlings emerge from their eggs at about the size of a newly-hatched chicken. Hatchlings in the same nest are of differing ages, with some having hatched as much as two weeks apart. Snowy owl chicks weigh only about 45 grams at birth, but they grow rapidly, gaining about three grams each day. They mature over the course of two years, at which point they weigh approximately 4.5 pounds. Javier Piva Flos/Getty Images   Conservation Status There are approximately 200,000 snowy owls in North America. Despite conservation efforts, these unique owls are now considered to be a vulnerable species. While breeding areas are usually far away from human interference, climate change is impacting the snowy owls Arctic habitat; the number of these birds is on the decline. Relatives of the Horned Owl Until recently, snowy owls were the only member of the genus Nyctea but recent molecular studies showed snowy owls to be close relatives of the horned owls. As a result, taxonomists have moved snowy owls to the genus Bubo. Other members of the genus Bubo include the American horned owls and the Old World eagle-owls. Like other horned owls, snowy owls have ear tufts but they are small and usually kept tucked away. Sources â€Å"Basic Facts About Snowy Owls.†Ã‚  Defenders of Wildlife, 10 Jan. 2019, defenders.org/snowy-owl/basic-facts.â€Å"Snowy Owl.†Ã‚  Audubon, 21 Mar. 2019, www.audubon.org/field-guide/bird/snowy-owl.â€Å"Snowy Owl.†Ã‚  National Geographic, 24 Sept. 2018, www.nationalgeographic.com/animals/birds/s/snowy-owl/.

Audit Planning Coursework Example | Topics and Well Written Essays - 500 words

Audit Planning - Coursework Example For the success of the planning process, an auditor has to observe several steps. They include risk assessment, conducting a survey, planning meeting and definition of scope and objectives of the audit. Risk assessment is purposed to determine the risks involved in the planned audit. These risks if any can be evaluated to determine their levels and whether or not to be included in the current review. It also helps in deciding the extent of involvement of professionals with the specialised skills during the review process. In most occasions, these assessments are discussed with the firm’s department to get their perspective on the risks identified and their views. A preliminary survey is conducted to allow an auditor get an overall understanding of the various departments within an organization and their operations. This helps in planning on time and resource allocation to the different audit areas. It also helps in identification of the direction, management and supervision of resources. This stage also enables auditors to design the strategy of the audit process for effective exercise and on time management. After completion of the survey, a meeting with the organization’s heads is usually convened. This usually is carried out to discuss the strategies for the audit, and ensure that the information gathered during the survey is accurate and reviewing the level of risk assessed. Discussion of the audit scope and objectives is done at this stage. Documentation of the overall audit strategy and plan is compiled, and then the review process is then rolled to the firm. An effective audit process can be executed if there exists a clear understanding of the client’s business operations. It is usually a challenge for many auditors to perform their operations without having knowledge of their client’s business. It is a requirement in the International Standards on Auditing for the auditor to have knowledge about the company and its

Country Analysis Paper on Norway Essay Example | Topics and Well Written Essays - 3250 words

Country Analysis Paper on Norway - Essay Example Good economic performances continue support to areas losing residents in Norway. The Nordic model follows both justice and aggressive apprehensions. Maintaining the main features of the settlement pattern is an eternal objective of the nation. Policies mainly target thinly populated areas, with stress on service delivery and competitiveness. Measures are based on employment oriented economic methods and service delivery balancing. Diagnosis of regional competitiveness advantages could improve the design of policy tools. Regional innovation and competitiveness policies involve a lot of aspects. The role of major urban areas in knowledge production and circulation should be better considered. Recent emphasis on city attractiveness and competitiveness, particularly in Oslo, create the basis for an open city policy. The role of small and medium sized cities needs to be better incorporated into regional innovation strategies. Place-based policy approaches can enhance the impact of regiona l competitiveness and innovation policies. Depopulation and ageing in more than half of Norwegian municipalities affect the cost of services. Population decline produces apprehensions about school closures and staffing problems.

Historians Can't Speculate Essay Example | Topics and Well Written Essays - 3500 words

Historians Can't Speculate - Essay Example Yet when the historical records of an event such as American slavery tend to be biased towards the view of it as just another type of economic enterprise, there is clear value in what might be termed memory or the an attempt to explore what actually occurred using the human imagination as a spur rather than 'actual' historical records. Beloved is a prime example of such an attempt. Historians are concerned with events which can be assigned to specific time-space locations, events which are (or were) in principle observable or perceivable, whereas imaginary writers . . . are concerned with both these kinds of events and imagined, hypothetical, or invented ones. It is interesting to note that White's definition provides for an area of coincidence between the work of the historian and the work of the imaginary writer (such as Morrison, who is a novelist) by suggesting that novelists deal with historical events as well as historians, although they may also include the fictional elements that the historian supposedly does not. As White suggests, it was after the Enlightenment and the French Revolution that history and literature started to part company. By the early 1800's "it became conventional, at least among historians, to identify truth with fact and to regard fiction as the opposite of the truth" (White, p.123) (emphasis added). This might seem almost childishly simplistic to many scholars today, but it can be related to the supposed triumph of the 'rational', often in the form of Science, over the irrational. The word science means "to know" (from the Latin scio, to know) and the only thing that can be "known" is a fact. Fiction was thus "a hindrance to the understanding of reality rather than as a way of apprehending it"(White, p.123). History was thus placed within a hierarchy that placed it indelibly above, and thus superior, to that of mere fiction. Many historians of this era did not seem to consider the fact that the histories which they were writing depended a lot upon which facts were being considered, and that this just as much choice and imagination went into writing them as in fiction. History dealt with facts, and thus the truth, while fiction dealt with non-facts, and thus lies. It was only during the Twentieth Century that history and fiction started their long journey back towards one another. In the Nineteenth Century historians did not realize that which seems self-evident today: "facts do not speak for themselves, but that the historian speaks for them, speaks on their behalf, and fashions the fragments of the past into a whole whose whole integrity is - in its representation - a purely discursive one" (White, p.125). It is this "fashioning" which makes history resemble the process a fictional writer goes through when she is creating a world of characters. The historian takes a historical event, for example, the Fall of the Bastille, and gives meaning to it by creating a kaleidoscope through which the event can be seen. The fact that the Bastille fell cannot be disputed; what that falling means can be. Both history and fiction deal with meaning, and thus can be regarded as different techniques with the same end in mind.  Ã‚  

How Off Site Construction Construction Essay

How Off Site Construction Construction Essay This dissertation will discuss the effect of Modern Methods of Construction (MMC) and particularly the Off-Site Construction (OSC), on the building sector today, and how these methods will contribute to help and resolve social, financial, and environmental difficulties that facing the UK. Off-site construction is an application of modern methods of construction MMC where building sector meets the industrial sector, or by other word, a fusion between building and manufacturing. Off-site construction is where any of building components, or even a whole building, manufactured in factories away from the actual site where the building will be sited, or simply is where the construction site is different from the building site. Off-site construction has different terms, terms like (prefabrication, off-site assembly, factory assembly, pre-assembly, off-site manufacture, etc.). The term off-site construction is generally used nowadays to any part of the construction process that takes place in factories. Off-site construction is not new, in the 20th century specifically in the post wartime, off-site construction (that time the term used probably was factory assembly or prefabrication construction) were needed to replace rapidly buildings which were destroyed or damaged during the war, But due to the lack of technology and modern production techniques, development in lightweights, high-strength materials, and new modern methods of construction that today is available, it gained unfortunately negative significance. The time of the wheelbarrow is finished, announced Jean Prouvà © in 1947, echoing Le Corbusier.We need usinà ©es maisons, homes produced in the factories Since then, a further sixty years have passed: the manufacturing industry has come with story of success of the mechanization, has enhanced electronics and grafting. Today industrial automation and manufactures from shoes to personal computers, and from planes to crackers, all now machine-made, in Seattle as a small village in China. The building construction is still the same. With very few exceptions, the building remains largely an object made by hand with traditional techniques. And the only construction industry still relies to logical and largely pre-industrial processes. With known effects: low productivity, forecast time and cost much more random, exposed to all levels of quality and possibilities and approximations of production conditions are vary widely, backward technologies and unskilled work. Why choose off-site construction now? What is so different from the traditional way of construction? Why is sustainability constantly being brought up? Before I examine these points, I have to mention some important facts that have already occurred. Since the beginning of the century, it is increasingly being talked about and discussed, the world and its climate changing. United Nations ask for action on it. The world met in a summit in Copenhagen to discuss how they can resolve the raising temperature that might cause damages and risks to the global, and how to reduce energy and CO2 emission. Why I mentioned climate change and we are talking about off-site construction? The answer is surprisingly, buildings are responsible for about one third of global energy consumption and if we add the energy used for construction the amount can easily be increased to the half. All of this means that we need to build very efficient houses and in an efficient way, and thats can be achievable only by off-site construction. There is a severe accommodation shortage in the UK. The Government has announced plans for the construction of 200,000 new houses per year, but that target has never achieved yet. Off-site construction can help the accommodation industry to achieve that target where fast delivery is needed. Speedier delivery in construction is one of the potential advantages of off-site construction and research showed that it can reduce the time of construction process to the half because it takes place in a desirable condition away from the unpredictable weather that can affect and delay the process on-site. And research showed that it can reduce the time of construction process to the half because it takes place in a desirable condition away from the unpredictable weather, factory built accommodation. Offsite construction already features in the production of social accommodation.elderly.jpg Skill shortages in the UK construction industry are a severe problem. In 2001 the UK construction industry estimated it needed to train an extra 74,000 skilled workers every year for five years just to make up for the shortages of bricklayers, plumbers and electricians (Verbus System, 2006). In 2009, the chartered institute of building (CIOB) concluded a third research on skill shortages, and the result again showed that the construction industry is still suffering a skills shortage, which is likely to continue to be a challenge for the building sector. Off-site construction can play an important role to resolve this issue. The research showed, compared to more traditional techniques, off-site construction can reduce on-site labour requirements to less than a quarter. This result achieved from some work took place off-site. Off-site work involves different labour that is not under pressure as the on-site workforce. Off-site construction and modern methods of construction (MMC) can therefore make better use of scarce labour. 1.5 DISSERTATION STRUCTURE The dissertation consists of an introduction chapter, three main chapters and conclusion chapter; Chapter two discuss the advantages of off-site construction for the building sector, society, and the environment. The chapter also will discuss the conditions in order to gain the full advantages of off-site construction. Chapter three explain the types and forms of off-site construction, and where off-site construction takes place in the building and in the construction process. Off-site construction takes place in different areas of the building, so how off-site construction will incorporate with the mainstream construction process. Chapter four show and examine some of off-site construction case studies and in which type of building it takes place. CHAPTER TWO: ADVANTAGES OF OFF-SITE CONSTRUCTION 2.1 INTRODUCTION Off-site construction, as I mentioned, is part of modern methods of construction (MMC) and is referred to as any of the components of the building built in a high quality controlled factories where they use advanced techniques to manufacture highly specialised doors, windows, stairs, wall panels, frame structure, and complete volumetric pods and then transport them to the location where it will be used and to be assembled on-site. Off-site construction has many advantages that are why nowadays there are more companies and contractors using this method rather than the traditional way of construction, even governments make more pressure to use this method to speed up housing delivery. Modern methods of construction can provide good quality homes with less on-site labour, in a shorter time, with at least the same building performance and at similar cost when compared to more established techniques. Off-site manufacturing and partnering processes increasingly play a part in solving todays problem of moving towards a sustainable housing industry. The advantages of off-site construction can be classified into two types; Business advantages, social environmental advantages Modern construction methods can produce important benefits for housing authorities and developers, not the least of which is the reduced emphasis on on-site activity. This is particularly important in a time of increasing demands on an already stretched labour force. As with any new way of doing things there are risks, but these can be mitigated through good project planning and management (Sir John Bourn, head of the National Audit Office, 2005). 2.2 ADVANTAGES Less time in construction process, cost predictability, higher quality,helping the society and the environment, resolving skilled labour shortage, reduce health safety risks,and helping the business the economy. These are key advantages of off-site construction. 2.2.1 Reduced construction time Business advantages give a huge encouragement to the contractors and designers to use more off-site construction components with their design and building processes. The greater speed of manufacturing and on-site assembling is an important factor for business gain. Earlier the delivery of the building means earlier the return of the investment. Modular construction for example, that is an off-site construction, is up to 40-60% quicker than traditional building methods. The predictability of the delivery also is very important for the financial calculation of the business in terms of cost and revenue. The manufacturing process of the components in quality controlled factories is nearly accurately estimated as well as the delivery to the site and the assembly operation. 2.2.2 Cost Predictability Cost-effectiveness is an important factor to show the difference between the off-site construction method and the conventional one. Approximately, around 80% of the construction costs are fixed within the first 20% of the design process. The graph below highlights the potential for cost reduction and alternatively the resistance to the cost of change during the project life. As the project progresses, the opportunities for implementing variation or change reduce and the consequent costs associated with these variations rise substantially, Where off-site production techniques are to be used, these should be introduced early in the process. While off-site construction has tended in the past to be more expensive than brick block, now is being reduced to the same level due to the innovation of more techniques and to the variety of the components, and these bringing even greater economies. 2.2.3 Superior Quality Off-site manufacture for building components significantly improves the quality and the efficiency of the building due to high standard of quality control and test. Buildings exceed requirements on sound and thermal insulation levels, so this means that are more sustainable. 2.2.4 Help the society and the environment Off-site construction has also can help the society and the environment. Millions of affordable homes are required to meet growing demand, and there is increasing pressure to further improve efficiency and sustainability performance during construction and throughout the lifetime of the buildings. Off-site construction is environmentally friendly if it is planned well from the early stages of design and by integrating all the supply chain together. Less energy is generally required to develop the modules or off-site manufactured components. With improved process control ,buildings are pre-engineered each exactly the same and so can be adapted for ease of tiling and this should lead to reduced levels of waste on site of up to 70% and subsequent costs. In addition, with improved control of materials flow, raw materials can be recycled rather than skipped as often happens on site. The advantage of using OSC methods related to the reduction of waste to landfill are that the material usage in the factory is reduced up to 90% by the  careful design and procurement of materials, reducing the  amount of waste generated  both on-site and off-site. Offsite manufacturing was identified as a key potential method for promoting sustainability within the construction industry. Sustainability is increased as sound and thermal insulation are improved. Reduced time on site means less disruption to neighbouring residents or businesses. 2.2.5Reducing reliance on skilled labour While there is a significant shortage of housing in the UK, and the government plans to build more accommodation houses, there is another problem facing to achieve these plans as well the building industry a whole which is the skills shortages bricklayers, plumbers and electricians. Off-site construction helps to build more houses by reducing reliance on increasingly scarce skilled labour by reducing the number of labour where semi-skilled factory labour can be used during the construction of modules. 2.2.6 Improve Health and safety Health and safety issue also give off-site construction an advantage, it has been proven to be a safer method of construction because there are fewer components involved than traditional methods and there is no need for high quantity of labour on-site for the assembly process. 2.2.7 Business integration and economy development Off-site construction helps to integrate the supply chain. When executed effectively, the off-site construction process involves key manufacturers and suppliers early in the feasibility and design stages of the project. This ensures that the specialist skills and knowledge of these key suppliers are embedded within the project and can influence the design and construction phases of the project. Where appropriate these key suppliers should be given ownership of the design and involved fully in the execution of delivery, storage and movements of materials and components. CHAPTER THREE: OFF-SITE CONSTRUCTION! WHERE IT TAKES PLACE? 3.1Forms of off-site construction Off-site construction can take a number of forms. The form and extent of acceptance within the projects will depend on:the type of project: Is there a large proportion of duplication or replication? for example; in hotels and hostels, the type of client: Is the client a one-off or repeat client?, and the relationships and the arrangements between the project members. Off-site buildings and components systems range from small bolt-together sections to virtually complete buildings. Systems can be categorised as: Sub-assemblies Frames Panels (open or closed) Volumetric system Hybrids system 3.1.1 Sub-assemblies Sub-assemblies are the most traditional and widely used system in off-site manufacturing which is being used for many generations. Thistype of off-site construction can include elements using different type of materials such as concrete beams, block floors, and foundations. Prefabricated foundation systems can consist of precast, post-tensioned, concrete beams. Prefabricated beam installation in progress on piles. The beams can be omittedand modular structures can be installed to span directly onto piles and pile caps Photograph courtesy of Van Elle An additional examples for sub- assemblies systems are the glass reinforced plastic for chimneys, steel for curtain walling, and timber stairs. 3.1.2 Frames Framed structures, which are pre-assembled in factories, supply the structural support to buildings and are not something new feature in construction. Lightweight pre-assembled frames which can be delivered promptly to the site, speeding up the construction times for the main structural elements. The benefit of pre-assembled framed structures, that can help of reducing site cutting and the inaccuracies that can arise from it.Untitled-1.jpg Insulated steel frame building system Photograph courtesy of Fusion An example of framed structure is the steel frame module. Steel works in off-site construction are taking the most important part of the factory controlled construction due to the characteristics of the steel itself that can be shaped and moulded in any form; the result is light strong steel modules structures. The UK construction market is one of the most steel intensive in the world, with steel proving to be the material of choice for UK architects and structural engineers in the multi-storey building market. The 2007 Market Shares Survey figures show steel construction consistently takes in excess of 70 per cent over double the market share compared to when the survey was first carried out in the early 1980s.(Housebuilder Developer. 2008). The Steel Construction Institute has carried out a study of different construction projects using various levels of off-site steel construction technologies in busy urban sites. The goal of the study was to recognize the benefits of off-site construction relating to the reduction of the disruption caused to local residents by the construction operations. The study also aimed to quantify these benefits in terms of the reduction in dust, noise, vehicle circulation and the impact of site-generated waste on the environment. 3.1.3 Panels Panels are two dimensional frame that consist both the structural and the infill element, are sealed together on site. Example of panels are pre-assembled floor, wall, and roof panels. Using the right sealants are very important to gain the benefit of off-site manufactured panels in order to stand up the frames rapidly. The simplest form of off-site manufactured panel system is lightweight infill panels that are fixed to the structural frame, where the most complex form are the prefabricated sandwich panels which consist of both, the structural element, internal and external finishes. 3.1.4 Volumetric System Volumetric system is the frame and panel systems, and when the building is assembled and built from a series of volumetric steel or timber modules, connected together to form a room or groups of rooms to form complete structure. Modular construction is also a term used to refer the volumetric assemblies. While the foundations are being prepared under factory conditions, the modules are manufactured and finished (or partially finished) off-site, under factory conditions, then transported to the building site and assembled and connected to the foundations, then added the exterior cladding and the roof. Modular construction is more sustainable than traditional techniques because of the minimum foundations that required and because it is built under factory conditions, the modules are in better quality and defects are minimized. Modular construction uses the same techniques from the industrial sector but the result does not look like mass production product. Sophisticated modules and panels can be produced and can be easily customised by the clients requirements, and with new advanced techniques finishes: cladding and roofing, give the building its natural skin that suites the surrounding. 3.1.5 Hybrids System Plant rooms Plant room is a room or space in a building dedicated to the mechanical and electrical equipments and then they need an intensive labour. If plant rooms built off-site where there is cheaper labour, this can be more economically. Other advantage of plant rooms built in factory is if a project in time difficulties, always the installation of the services is squeezed, so using modular plant rooms certainly will help to avoid this problem. Using system-engineering principles, the resulting prototype has been developed principally for use in the construction of two and seven storey residential developments. It is a hybrid of frame and infill panels, the prototype enables construction in stick form, panels or 3D volumetric units, and works on the principle of a frame and infill system. The mainframe is hot-rolled steel and typically uses regular or square hollow sections with a width of 100mm for both columns and beams to provide a standard interface that can be in filled with floor and non-load bearing wall panels to complete the building. The prototype is based on currently available main components, which can be connected in a variety of ways to suit the individual project to allow flexibility in the level of work carried out off-site. Connections include innovative bolt connections to allow complete demountability, location systems and welded connections, all of which can be used in isolation or as part of a combined system. Bathrooms Pods Bathroom construction process can use Off-site construction technology, which in compare to the traditional way, would normally be carried out on-site. If we remove the construction process of the bathrooms to a controlled factory environment, bathrooms will become more ecological, functional, and with lower building costs. Bathrooms that we call them smart will also become more common with highly environmentally toilets and showers systems and with more advanced technology like tapes with sensors. The quality of bathrooms pods is far superior to the traditional on-site construction, more stylish, with high quality materials, and better for the environment in terms of a lower carbon footprint, lower levels of waste and reduced transportation of components. Bathroom pods are a very economically solution when it integrate with the whole construction process in large quantities such as; student accommodations, hotels, hostels, hospitals, and prisons.3.jpg Walker Modular CHAPTER FOUR: CASE STUDIES 4.1 British Land Ropemaker site, London Ropemaker is a commercial building for British Land, one of the UKs largest Real Estate Investment Trust. It is built in an eminent site in London. The 21 storey and three basement levels has 55,000 square metres net lettable space. The high profile building has impressive green certifications achievement including a BREEAM excellent rating. The development has been realised using off-site construction technologies in a large number of parts in the building. This study aimed to evaluate two products manufactured off-site; a modular walling system Podwall from Swift Horseman, and Technik flooring system supplied by Grants LTD. The research aimed to compare in deep analysis off-site construction techniques products to the traditional way of construction in terms of; waste on-site and off-site, resources needed on site, efficiency and productivity, cost, environmental impact analysis and end of life assessment, health and safety, and installation time. Features of the Podwall system (Swift Horsman. 2010) A flexible modular walling system incorporating finishes and services. All elements manufactured off site in a controlled environment. Innovative fit out solution providing high quality female, male, and disabled toilet units throughout the development. PODWALL research results Performance breakdown (man hours on site) Podwall saved approximately 40% to programme. Each floor at Ropemaker had an 11 week programme to install the Podwall (3 blocks per floor one ladies, one gentlemen and one disabled toilet), which would be equivalent to 15 ½ weeks for traditional fit out. Podwall waste Because the Podwall is manufactured off-site the waste on site is reduced. The largest proportion of waste generated is in the packaging, which ensures the product is protected between factory and site. Across the Ropemaker site a total of approximately 213m3 of waste was produced for all Podwall washrooms. Given the low levels of waste observed during the monitoring of the Podwall, traditional waste would considerably exceed the Podwall waste volumes. The percentage of materials recycled from Ropemaker frequently exceeds 85%. At Ropemaker the Podwall washroom package has a value of approximately  £6m, with 54 toilet blocks being delivered across 1969m2 The main differences in cost between the Podwall and the traditional system are in services installation and cubicles. This is because services are integrated off site into the walls and cubicles for the Podwall which explains the greater cost of these elements, whereas with traditional build the cost of installing services on site is higher. The traditional costs do not account for indirect costs such as the increased cost of waste and removal thereof and the increased programme time to install the traditional product. 4.2 Case Study: Bewdley High School and Sixth Form, Worcestershire This case study involves a school and sixth form building based in Bewdley, Worcestershire. A new building which can meet the needs and expectations of this school is to be proposed, designed and implemented. The requirements are said to be a building which offers flexibility for the school and its occupiers as well as being a low-energy solution. The changing needs of the school means space needs to be provided to accommodate the new influx of around 360 pupils. Yorkon manufacturers, who are based in the city of York, have created a two-storey high building at their off-site location. Due to the nature of the build taking place away at York as an off-site project, the building only took a mere 22 weeks to put together compared to an on-site project which would take longer. This new building has become a project now boasting a title as not only one of the most sustainable modular buildings within the UK, but offers heating via biomass fuel and holds a complex passive and low energy ventilation system. The building comprises of 60 steel-framed modules and has clear internal spans measuring up to 12m for space planning flexibility within. The parts were brought in using cranes and windows and partitions were put into place. The effectiveness of pre-installing the windows and partitions off-site show the efficiency and speed of this new phenomenon. It is a desired and sought after concept to still incorporate off-site construction into the regular and more traditional building techniques. The fact the building has integrated off-site technology into its production whilst still being themed around a conventional and traditional design for a drama and dance studio, ultimately shows the two somewhat diverse approaches to construction working in harmony together. The building comprises a 12 classroom facility which may accommodate the schools Modern Languages, Humanities as well as English Departments. Furthermore, a designated creative-area is also catered for within the design concept as well as an area for an administrative centre. Its design features boast central-heating fuelled by biomass fuel thus being environmentally friendly by minimising harmful carbon emissions. Not only this, but the new building can offer all timber cladding from sources that are confirmed sustainable, a highly-glazed activity studio offering a plentiful amount of natural light and an appealing bespoke roof structure thats pleasing to the eye. Looking further into the buildings design concept in offering a complex passive ventilation system, we can see that the clever idea of well-ventilated rooms provide a more comforting area for study and teaching. This additional air-flow is thus providing better concentration and performance for all those working within the new building. This is achieved through something recognised as passive air-stacking. The sensors installed are there to monitor levels of both carbon dioxide as well as temperature. This enables fresher air to be drawn in accordingly when detected as too low. This is fed diagonally over radiators which prevent the possibility of unwelcome cold draughts. Any stale air from the room is passed out from the room via high capacity discharge terminals found on the roof. This ultimately creates a continuous regulation of new air flow replacing older air providing optimum air composition levels in each room. Professionals working at Yorkon have expressed their views in using off-site construction in this project amongst others. They voiced that the main decision to go for off-site production was speed in completing the project which was highly important in making sure the facility would be ready on time for the new quantity of pupils to be joining the school. Furthermore, Yorkon is keen to be recognised as a reputable name in supplying superior quality along with an eye for sophisticated and precise detail in the designs and bringing revolutionary new techniques to building which can change attitudes towards regular modular construction. This is all despite any challenging timescale. Yorkonis adamant their team has provided the required building which can boast quality, bespoke elements and flexibility along with highly favoured low energy, environmentally friendly and speedy results. (The new building has provided us with spacious accommodation and room sizes that are appropriate for our learning and teaching needs. It is visually pleasing from the outside and fits in well with the locality. Our students have been impressed with the design of the building and it has helped to develop a strong sense of pride in our school and working environment. The modular approach is a very good method of construction for schools as it limits the disruption to learning because of the speed of assembly. The building will be easy to expand and the design is sufficiently flexible to meet the changing needs of our students and curriculum development.-Julie Reilly, Head Teacher and Sixth Form centre.) 4.3 Case Study-Emergency Assessment Unit, University Hospital of North Tees. In this case study we are looking at the new revolutionary building which was designed to fulfil the needs of Interserve Project Services/North Tees and Hartlepool NHS Foundation Trust. The building will be located at the University Hospital of North Tees. The purpose-designed and built Emergency Assessment Unit has been required in order to reduce waiting times for much demanded emergency treatment. This is something the Government has planned as to drive down waiting times for patients. The amount of beds are needed to be increased at the Stockton site as well as the site needing to be able to provide a service to those needing emergency surgical care, based centrally on location rather than some distance away. The unit has promised to feature up-to-date emergency care and include specialist staff who can deal quickly and efficiently with a high number of patients thus increasing patient turnover. The solution to these needs was met through a  £2.8m Procure 21 project which was awarded to Yorkon manufacturers, based in York, by Interserve Project Services. Off-site construction and the installing of a 42-bed Emergency Assessment Unit was the aim for the new building as its production. The building included 42 steel-framed modules manufactured off-site at York and installed on-site in as little as a few days. Disruption was therefore limited and patients could rest unaware of any commotion. The 1,710m square single storey extension to the pre-existing department was astonishingly and impressively erected in just over six months from beginning to end. The building also can boast a full range of modern well-equipped facilities for any acute medical emergencies. Features are listed as including four-bed wards, single en-suite bedrooms, an isolation ward, high-dependency beds, consulting rooms, ward managers office, waiting area, Quiet room, staff changing facilities and rest room and also an interview room. Incorporated into the design were roof lights to increase any natural light in the centre of the unit and furthermore holds latest technology equipment. The installation of workstations are readily available and can be used at a patients bedside. This building proudly boasts to be one of the first units in the country to offer an electronic information board too. Looking to the comments of professionals working within the construction of this new high-tech building, we can see the positive influence of off-site technology in providing rapid, quality solutions to much needy clients